רדאר קליני AI | ||
|---|---|---|
הניסוי הקליני NCT06445023 (EMBARQ-CSU1) עבור אורטיקריה ספונטנית כרונית הוא פעיל, לא מגייס. לכל הפרטים, עיינו בתצוגת הכרטיסים של רדאר ניסויים קליניים ובכלי הגילוי של AI. אפשר גם לשאול כל דבר כאן. | ||
מחקר אחד תואם לקריטריוני המסנן
תצוגת כרטיסים
חזרה לחיפוש
סלדקס תרפיוטיקסA Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (EMBARQ-CSU1) שלב III 963
פרטי הניסויים הקליניים זמינים בעיקר באנגלית. רדאר קליני AI יכול לעזור! לחץ על 'הסבר את המחקר' כדי לצפות ולשוחח על מידע מהמחקר בשפה המועדפת עליך.
ניסוי קליני NCT06445023 (EMBARQ-CSU1) מתקיים כדי לבדוק את טיפול עבור אורטיקריה ספונטנית כרונית. זהו מחקר שלב III מסוג התערבותי שנמצא כעת במצב פעיל, לא מגייס. המחקר התחיל ב-11 ביולי 2024 ומתוכנן לכלול 963 משתתפים. המחקר מנוהל על ידי סלדקס תרפיוטיקס וצפוי להסתיים ב-1 באפריל 2027. מידע זה עודכן לאחרונה באתר ClinicalTrials.gov ב-27 בפברואר 2026.
סיכום קצר
The purpose of this study is to establish the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) inadequately controlled by non-sedating second generation H1-antihistamines in comparison to placebo.
תיאור מפורט
This is a global, multicenter, randomized, double-blind, parallel group, placebo-controlled phase 3 study investigating the efficacy, safety and tolerability of barzolvolimab in adult participants with Chronic Spontaneous Urticaria (CSU) who are symptomatic despite treatment with non-sedating second generation H1-antihistamines at 1-4 times the locally approved dose.
There is a screening period of up to 4 weeks, fol...
הצג עודכותרת רשמית
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab in Patients With Chronic Spontaneous Urticaria Who Remain Symptomatic Despite H1 Antihistamine Treatment (EMBARQ-CSU1)
מצבים רפואיים
אורטיקריה ספונטנית כרוניתמזהי מחקר נוספים
- EMBARQ-CSU1
- CDX0159-12
- 2024-513208-32-00 (מספר ניסוי של האיחוד האירופי (CTIS))
מספר NCT
תחילת המחקר (בפועל)
2024-07-11
עדכון אחרון שפורסם
2026-02-27
סיום המחקר (מוערך)
2027-04
משתתפים (מתוכנן)
963
סוג המחקר
התערבותי
שלב
שלב III
סטטוס
פעיל, לא מגייס
מילות מפתח
CDX-0159
barzolvolimab
chronic spontaneous urticaria
CSU
urticaria activity score
itch severity score
hives severity score
barzolvolimab
chronic spontaneous urticaria
CSU
urticaria activity score
itch severity score
hives severity score
מטרה ראשית
טיפול
הקצאת טיפול
אקראי
דגם מתערב
קבוצות מקבילות
עיוורון
מרובע
זרועות / התערבויות
| קבוצת משתתפים/זרוע | התערבות/טיפול |
|---|---|
ניסיbarzolvolimab 150 mg barzolvolimab given once as a 300 mg subcutaneous injection followed by 150 mg administered every 4 weeks for 52 weeks | barzolvolimab Subcutaneous Administration |
ניסיbarzolvolimab 300 mg barzolvolimab given once as a 450 mg subcutaneous injection followed by 300 mg administered every 8 weeks for 52 weeks | barzolvolimab Subcutaneous Administration |
ניסיPlacebo then barzolvolimab 150 mg Placebo injection subcutaneous every 4 weeks for 24 weeks and then barzolvolimab 300 mg followed by 150 mg administered every 4 weeks for 28 weeks. | barzolvolimab Subcutaneous Administration פלצבו תואם Matching placebo Subcutaneous Administration |
ניסיPlacebo then barzolvolimab 300 mg Placebo injection subcutaneous every 4 weeks for 24 weeks and then barzolvolimab 450 mg followed by 300 mg administered every 8 weeks for 28 weeks. | barzolvolimab Subcutaneous Administration פלצבו תואם Matching placebo Subcutaneous Administration |
מדדי תוצאה ראשיים
מדדי תוצאה משניים
| מדד תוצאה | תיאור המדידה | טווח זמן |
|---|---|---|
Mean change from baseline to Week 12 of UAS7 (Urticaria Activity Score) | Evaluate efficacy of barzolvolimab on urticaria activity as measured by urticaria activity score (UAS).
The UAS7 is a simple scoring system to evaluate urticaria signs and symptoms. It is based on scoring wheals (hive severity score) and itch (itch severity score) separately on a scale of 0 (no signs/symptoms) to 3 (intense signs/symptoms) over 7 days. The final score is calculated by adding together the daily scores, which can range from 0 to 6, for 7 days. This results in a maximum total score of 42, and a minimum possible score of 0. | From Day 1 (first dose) to Day 85 (Week 12) |
| מדד תוצאה | תיאור המדידה | טווח זמן |
|---|---|---|
Mean change from baseline to Week 12 of ISS7 (Itch Severity Score) | The ISS7 and HSS7 combined together make up the UAS7 scoring system to evaluate urticaria signs and symptoms. The ISS7 is the itch severity score for 7 days, the scores range from 0 to 21. | From Day 1 (first dose) to Day 85 (Week 12) |
Mean change from baseline to Week 12 of HSS7 (Hives Severity Score) | The ISS7 and HSS7 combined together make up the UAS7 scoring system to evaluate urticaria signs and symptoms. The HSS7 score is the wheal/hives severity score for 7 days, the scores range from 0 to 21. | From Day 1 (first dose) to Day 85 (Week 12) |
Percentage of participants with UAS7 = 0 at Week 12 | Proportion of participants who achieve complete absence of hives and itch (UAS7 = 0) at Week 12. | From Day 1 (first dose) to Day 85 (Week 12) |
Percentage of participants with UAS7 ≤ 6 at Week 12 | Proportion of participants who achieve control of their urticaria signs and symptoms (UAS7≤6) at Week 12. | From Day 1 (first dose) to Day 85 (Week 12) |
Percentage of participants with AAS7 > 0 at baseline with AAS7 = 0 at Week 12 | Proportion of participants with AAS7 \> 0 at Day 1 who achieved complete control (AAS7 = 0) at Week 12
Angioedema Activity Score over 7 days \[AAS7\] describes the effect of angioedema on five categories with 0 being none and 3 being most severe. The final score is calculated by adding together daily scores which can range from 0-15 for 7 days. The resulting maximum score is then 105. | From Day 1 (first dose) to Day 85 (Week 12) |
Mean change from baseline in UAS7 in participants refractory to omalizumab treatment at Week 12 | Evaluate efficacy of barzolvolimab on urticaria activity as measured by urticaria activity score (UAS) in participants who did not respond to or did not tolerate omalizumab.
The UAS7 is a simple scoring system to evaluate urticaria signs and symptoms. It is based on scoring wheals (hive severity score) and itch (itch severity score) separately on a scale of 0 (no signs/symptoms) to 3 (intense signs/symptoms) over 7 days. The final score is calculated by adding together the daily scores, which can range from 0 to 6, for 7 days. This results in a maximum total score of 42, and a minimum possible score of 0. | From Day 1 (first dose) to Day 85 (Week 12) |
Proportion of participants with UAS7 = 0 in participants refractory to omalizumab treatment at Week 12 | Proportion of participants who achieve complete absence of hives and itch (UAS7 = 0) at Week 12 in participants who did not respond to or did not tolerate omalizumab. | From Day 1 (first dose) to Day 85 (Week 12) |
Incidence of Treatment-Emergent Adverse Events | Occurrence of treatment emergent adverse events and serious adverse events during the study. | From Day 1 (first dose) to Day 477 (Week 68) |
עוזר השתתפות
קריטריוני זכאות
גילאים מוערכים למחקר
מבוגר, גיל שלישי
גיל מינימלי למחקר
18 Years
מגדרים מוערכים למחקר
הכל
Males and females, >/= 18 years of age.
Chronic spontaneous urticaria (CSU) >/= 6 months prior to Screening (Visit 1).
CSU despite the use of a stable regimen of second generation non-sedating H1-antihistamine as defined by:
- The presence of hives for >/= 6 weeks at any time prior to Visit 1 despite the use of non-sedating H1-antihistamines.
- Must be on a stable regimen of second generation non-sedating H1-antihistamine for >/= 4 weeks prior to study treatment.
- UAS7 of >/= 16 and ISS7 of >/= 8 during the 7 days prior to study treatment.
Normal blood counts and liver function tests.
Both males and females of child-bearing potential must agree to use highly effective contraceptives during the study and for 150 days after treatment.
Willing and able to complete a daily symptom electronic diary and comply with study visits.
Participants with and without prior biologic experience are eligible.
- Women who are pregnant or nursing.
- Chronic urticaria whose predominant manifestation is due to CIndU.
- Other diseases associated with urticaria.
- Active pruritic skin condition in addition to CSU.
- Medical condition that would cause additional risk or interfere with study procedures.
- Known HIV, hepatitis B or hepatitis C infection.
- Vaccination of a live vaccine within 30 days prior to Screening (Visit 1) (subjects must agree to avoid live vaccinations during the study). Inactivated vaccines are allowed such as seasonal influenza injection or authorized COVID-19 vaccine.
- History of anaphylaxis.
- Prior treatment with barzolvolimab.
There are additional criteria that your study doctor will review with you to confirm you are eligible for the study.
סלדקס תרפיוטיקסאין נתוני קשר.
235 מיקומי המחקר ב-21 מדינות
Alabama
Cahaba Dermatology Skin Health Center, Birmingham, Alabama, 35244, United States
California
First OC Dermatology - Fountain Valley, Fountain Valley, California, 92708, United States
310 Clinical Research, Inglewood, California, 90301, United States
Dermatology Research Associates, Los Angeles, California, 90045, United States
Focus Clinical Research - Los Angeles, Los Angeles, California, 91307, United States
Cura Clinical Research, Oxnard, California, 93030, United States
Allergy and Asthma Consultants, Redwood City, California, 94063, United States
Acclaim Clinical Research, San Diego, California, 92120, United States
West Dermatology Research Center, San Diego, California, 92121, United States
Therapeutics Clinical Research, San Diego, California, 92123, United States
Orso Health, Inc., Torrance, California, 90505, United States
Integrated Research of Inland, Inc., Upland, California, 91786, United States
Colorado
Western States Clinical Research Inc, Wheat Ridge, Colorado, 80033, United States
Florida
Encore Medical Research Boynton Beach, Boynton Beach, Florida, 33436, United States
Direct Helpers Research Center, Hialeah, Florida, 33012, United States
GSI Clinical Research, Margate, Florida, 33063, United States
International Dermatology Research Inc - Miami, Miami, Florida, 33144, United States
Miami Dade Medical Research Institute, LLC, Miami, Florida, 33176, United States
Sarasota Clinical Research, Sarasota, Florida, 34239, United States
GCP Global Clinical Professionals, LLC, St. Petersburg, Florida, 33705, United States
Idaho
Paradigm Clinical Research Boise, Boise, Idaho, 83709, United States
Illinois
Endeavor Health, Skokie, Illinois, 60077, United States
Indiana
Dawes Fretzin Clinical Research Group-7910 N Shadeland Ave, Indianapolis, Indiana, 46250, United States
Kentucky
DS Research of Kentucky, LLC, Louisville, Kentucky, 40241, United States
Allergy and Asthma Specialists PSC, Owensboro, Kentucky, 42301, United States
Louisiana
Clinical Trials Management LLC - Southshore Office, Metairie, Louisiana, 70006, United States
Maryland
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, 21224, United States
DermAssociates, LLC, Rockville, Maryland, 20850, United States
Institute For Asthma and Allergy, Wheaton, Maryland, 20902, United States
Michigan
David Fivenson MD Dermatolgy PLLC, Ann Arbor, Michigan, 48103, United States
Resp Medicine Research Institute of MI, Ypsilanti, Michigan, 48197, United States
Missouri
Dermatolgy and Skin Cancer Center, Lee's Summit, Missouri, 64064, United States
MediSearch, LLC, Saint Joseph, Missouri, 64506, United States
Montana
Montana Medical Research, Missoula, Montana, 59808, United States
Nevada
Excel Clinical Research - Las Vegas, Las Vegas, Nevada, 90301, United States
New Jersey
Allergy Partners of N.J., P.C., Ocean City, New Jersey, 07712, United States
New York
Finger Lakes Medical Research, PLLC, Cortland, New York, 13045, United States
Sadick Research Group, New York, New York, 10075, United States
Ohio
Bexley Dermatology Research, Bexley, Ohio, 43209, United States
Apex Clinical Research, Canton, Ohio, 44718, United States
Bernstein Clinical Research Center, LLC, Cincinnati, Ohio, 45236, United States
Wright State Physicians, Fairborn, Ohio, 45324, United States
Auni Allergy, Findlay, Ohio, 45840, United States
Apex Clinical Research Center, Mayfield Heights, Ohio, 44124, United States
Toledo Institute of Clinical Research, Toledo, Ohio, 43617, United States
Oklahoma
Allergy Asthma and Clinical Research Center, Oklahoma City, Oklahoma, 73120, United States
Oregon
Portland Allergy and Asthma, Clackamas, Oregon, 97015, United States
Oregon Medical Research Center, Portland, Oregon, 97201, United States
Pennsylvania
Clinical Research Philadelphia, LLC, Philadelphia, Pennsylvania, 18114, United States
South Carolina
National Allergy and Asthma Research, LLC - CRN - PPDS, North Charleston, South Carolina, 29420, United States
Texas
Alina Clinical Trials, Dallas, Texas, 75225, United States
Zenos Clinical Research, Dallas, Texas, 75230, United States
Epic Clinical Research, Lewisville, Texas, 75057, United States
VAST Clinical Research - Plano, Plano, Texas, 75033, United States
STAAMP Research, LLC - CRN, San Antonio, Texas, 78229, United States
Allergy and Asthma Care of Waco, Waco, Texas, 76712, United States
Utah
University of Utah - MidValley Dermatology - PPDS, Murray, Utah, 84107, United States
Washington
Premier Clinical Research, Spokane, Washington, 99202, United States
Buenos Aires
Buenos Aires Skin, Buenos Aires, Buenos Aires, C1054, Argentina
Fundacion Cidea, Buenos Aires, Buenos Aires, C1121ABE, Argentina
CEMLO:Centro de Especialidades Medicas Lobos, Lobos, Buenos Aires, 7240, Argentina
Buenos Aires F.D.
Hospital Italiano De Buenos Aires, Buenos Aires, Buenos Aires F.D., 1199, Argentina
Conexa Investigacion Clinica, CABA, Buenos Aires F.D., 1012, Argentina
Aprillus Asistencia e Investigacion, CABA, Buenos Aires F.D., 1406, Argentina
CARE- Centro de Alergia y Enfermedades Respiratorias, CABA, Buenos Aires F.D., C14141AIF, Argentina
Sante Fe
Centro Respiratorio Infantil, Rosario, Sante Fe, 2000, Argentina
Instituto de Especialidades de Salud Rosario, Rosario, Sante Fe, 2000, Argentina
Servicio de Investigacion de Patologias Alergicas, Rosario, Sante Fe, 2000, Argentina
Instituto Medico de la Fundacion Estudios Clinicos, Rosario, Sante Fe, S2000DEJ, Argentina
Tucumán Province
C.I.C.E 9 de Julio - Sanatorio 9 de Julio S.A., San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Clinica Mayo, San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Centro de Investigaciones Medicas Tucuman, San Miguel de Tucumán, Tucumán Province, T4000AXL, Argentina
Centro Médico Vitae, Buenos Aires, Argentina
Instituto de Alergia e Inmunologia del Sur, Buenos Aires, Argentina
Antwerpen
UZ Antwerp, Edegem, Antwerpen, 2650, Belgium
Vlaams Brabant
UZ Leuven, Leuven, Vlaams Brabant, 3000, Belgium
UZ Brussel, Brussels, 1090, Belgium
Saint Luc, Brussels, 1200, Belgium
CHU de Liège, Brussels, Belgium
Hôpital Erasme - Erasme Medical Center - PPDS, Brussels, Belgium
UZ Gent, Ghent, 9000, Belgium
Dermatologie Maldegem, Maldegem, 9990, Belgium
AlergoAlpha Allergia e Immunologia, Barueri, Brazil
Instituto de Pesquisas Clínicas LTDA Brasilia, Brasília, Brazil
Fundação Universidade de Caxias do Sul - Instituto de Pesquisas em Saúde, Caxias do Sul, Brazil
Centro Paraibano de Pesquisas e Estudos Clínicos, João Pessoa, Brazil
Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil
Hospital Universitário Clementino Fraga Filho (UFRJ), Rio de Janeiro, Brazil
Clinica IBIS, Salvador, Brazil
Centro de Estudos de Pneumologia da Faculdade de Medecina do ABC, Santo André, Brazil
Centro de Pesquisa SVRI Hospital e Maternidade Christóvão da Gama, Santo André, Brazil
Clínica de Alergia Martti Antila, São Paulo, Brazil
Vidamed Care Clínica E Residência, Vitória, Brazil
"Medical center MedTech Services" OOD, Haskovo, 6304, Bulgaria
Diagnostic Consultative Center Pulmed, Plovdiv, Bulgaria
Aipsimpa D-R Talyat Sali Cholak Eood, Razgrad, 7200, Bulgaria
Medical Center Iskar EOOD, Sofia, 1000, Bulgaria
MC Excelsior OOD, Sofia, 1407, Bulgaria
DCC Fokus - 5 OOD LZIBP, Sofia, 1463, Bulgaria
Medical Center Hera EOOD, Sofia, 1510, Bulgaria
UMHATEM " N.I.Pirogov", Sofia, 1606, Bulgaria
Medical Center Pulmovision, Sofia, 1756, Bulgaria
MBAL Sv. Panteleymon AD, Yambol, 8600, Bulgaria
Alberta
Alberta DermaSurgery Centre - Probity - PPDS, Edmonton, Alberta, Canada
Newfoundland and Labrador
Skincare Research, St. John's, Newfoundland and Labrador, Canada
Ontario
Triple A Lab, Hamilton, Ontario, L8S1G5, Canada
Lynderm Research Inc, Markham, Ontario, L3P 1X3, Canada
Centre for Dermatology and Cosmetic Surgery, Richmond Hill, Ontario, L4B 1A5, Canada
Canadian Dermatology Centre - Probity - PPDS, Toronto, Ontario, M3B 0A7, Canada
Evidence Based Medical Educator Inc., Toronto, Ontario, M5G1E2, Canada
Rejuvenation Dermatology and Aesthetics, Calgary, Canada
Fakultní nemocnice Královské Vinohrady, Dermatovenerologická klinika, Prague, 10034, Czechia
Sanatorium profesora Arenbergera, Prague, 110 00, Czechia
Kožní ambulance Fialová, s.r.o., Prague, 160 00, Czechia
Fakultní nemocnice Bulovka, Dermatovenerologická klinika, Prague, 18081, Czechia
Aarhus Universitetshospital, Aarhus N, 8200, Denmark
Bispebjerg Hospital, Copenhagen NV, 2400, Denmark
Gentofte Hospital, Hellerup, 2900, Denmark
Rhone
Hospices Civils de Lyon - Hôpital Lyon Sud, Pierre-Bénite, Rhone, 69310, France
CHU de Grenoble Alpes - Hôpital Michallon, La Tronche, France
Cabinet du Dr Ruer-Mulard Mireille, Martigues, France
CHRU Nantes Hôtel Dieu, Nantes, 44093, France
CHU de Nice-Hôpital L'Archet, Nice, 06202, France
Hôpital La Pitié Salpêtrière, Paris, 75013, France
CHRU Rouen - Hôpital Charles-Nicolle, Rouen, France
Baden-Wurttemberg
Praxis Dr. Beate Schwarz, Langenau, Baden-Wurttemberg, 89129, Germany
Hesse
Rosenpark Research GmbH, Darmstadt, Hesse, 64283, Germany
Lower Saxony
Siteworks Prüfzentrum Lohne - PPDS, Löhne, Lower Saxony, 49393, Germany
North Rhine-Westphalia
ProDerma, Dülmen, North Rhine-Westphalia, 48249, Germany
Schleswig-Holstein
UKSH Kiel, Kiel, Schleswig-Holstein, 24105, Germany
Medizinisches Versorgungszentrum DermaKiel GmbH, Kiel, Schleswig-Holstein, 24148, Germany
Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP - Berlin, Berlin, Germany
Studienzentrum an der Hase Weyergraf / Frick / Heiber GbR, Bramsche, 49565, Germany
Dermatologie Quist, Mainz, 55128, Germany
LMU Klinikum der Universität München, München, Germany
Naval Hospital of Athens, Athens, 11521, Greece
Andreas Syggros Hospital, Athens, 16121, Greece
Attikon General University Hospital, Attiki, 12462, Greece
General Hospital of Thessaloniki 'Papageorgiou', Thessaloniki, 56403, Greece
Azienda Ospedaliero Universitaria delle Marche, Ancona, 60128, Italy
ASST Carlo Poma, Mantova, 46100, Italy
Istituti Clinici Scientifici Maugeri IRCCS, Milan, 20138, Italy
Azienda Ospedaliera Universitaria Federico II, Naples, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, 20128, Italy
Centro Ricerche Cliniche Verona s.r.l./Ospedale G.B. Rossi Borgo Roma, Verona, 37134, Italy
Hospital Pulau Pinang, George Town, Malaysia
Hospital Raja Permaisuri Bainun, Ipoh, Malaysia
Hospital Sultan Ismail, Johor Bahru, Malaysia
Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
Hospital Umum Sarawak, Kuching, Malaysia
Clinica Internacional - Sede Lima, Lima, Peru
Clinica Ricardo Palma, Lima, Peru
Clinica San Felipe, Lima, Peru
Medic Ser S.A.C. Auna Clinica Delgado, Lima, Peru
NZOZ Specjalistyczny Ośrodek Dermatologiczny "DERMAL", Bialystok, 15-453, Poland
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny Anna Ploszczuk, Bialystok, Poland
Pratia Bydgoszcz, Bydgoszcz, 85-796, Poland
Ambulatorium Sp. zo.o., Elblag, Poland
Centrum Badan Klinicznych PI-House Sp. z o.o, Gdansk, 80-546, Poland
"SYNEXUS POLSKA" sp. z o.o. Odział w Katowicach, Katowice, 40-040, Poland
Centrum Medyczne Katowice - PRATIA - PPDS, Katowice, 40-081, Poland
Polimedica PTG Kielce, Kielce, 25-355, Poland
Centrum Nowoczesnych Terapii "Dobry Lekarz" Sp. o.o., Krakow, 31-011, Poland
Santa Familia PTG Łódź, Lodz, 90-302, Poland
Oddzial Kliniczny Chorob Wewnetrznych, Astmy i Alergii z Odcinkiem dla Dzieci, Uniwesytecki Szpital Kliniczny nr 1 im. N. Barlickiego w Lodzi, Lodz, Poland
Pratia S.A. Centrum Medyczne Pratia Poznań, Poznan, 60-185, Poland
Specjalistyczna Przychodnai Lekarska Alergo-Med Sp. z o.o., Poznan, Poland
Synexus Polska Sp. z o.o. - Poznaniu, Poznan, Poland
NSZOZ Puls-Med Anna Bogusz, Agnieszka Musielak spolka jawna, Skarżysko-Kamienna, 26-110, Poland
Laser Clinic S.C, Szczecin, 70-332, Poland
MICS Centrum Medyczne Torun, Torun, 87-100, Poland
Klinika Ambroziak Dermatologia, Warsaw, 02-953, Poland
Royalderm Agnieszka Nawrocka, Warsaw, 02-962, Poland
FutureMeds - Targowek - PPDS, Warsaw, Poland
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Dr hab. Med. Eleonory Reicher, Warsaw, Poland
Ginemedica, Wroclaw, 50-414, Poland
Diagnostic Consultative Center Pulmed, Wroclaw, 50-566, Poland
Przychodnia FutureMeds Wroclaw, Wroclaw, 53-673, Poland
EuroMediCare Szpital Specjalistyczny z Przychodnia we Wroclawiu, Wroclaw, 54-144, Poland
Slaski Park Technologii Medycznych Kardio-Med Silesia Sp. z o. o., Zabrze, Poland
ULS da Região de Aveiro, EPE - Hospital Infante D. Pedro, Aveiro, Portugal
Centro Clínico Académico, Braga - Hospital de Braga, Braga, 4710-243, Portugal
ULS de Coimbra, EPE - Hospitais da Universidade de Coimbra, Coimbra, 3004-561, Portugal
Hospital Lusiadas Lisboa, Lisbon, 1500-458, Portugal
Unidade Local de Saúde de Santa Maria, Lisbon, Portugal
ULS de Matosinhos, EPE - Hospital Pedro Hispano, Matosinhos Municipality, Portugal
ULS de Santo António, EPE - Hospital de Santo António, Porto, 4050-342, Portugal
ULS da Arrábida, EPE - Hospital de São Bernardo, Setúbal, 2910-548, Portugal
Unidade Local de Saúde de Gaia/Espinho - Unidade I, Vila Nova de Gaia, Portugal
Free State
Iatros International, Bloemfontein, Free State, 9301, South Africa
Gauteng
Worthwhile Clinical Trials, Benoni, Gauteng, 1501, South Africa
Ubuntu Clinical Research, Krugersdorp, Gauteng, 1739, South Africa
Newtown Clinical Research Centre, Newtown, Gauteng, 2001, South Africa
About Allergy, Pretoria, Gauteng, 0181, South Africa
FCRN Clinical Trial Centre, Vereeniging, Gauteng, 1935, South Africa
KwaZulu-Natal
Synapta Clinical Research, Durban, KwaZulu-Natal, 4001, South Africa
Western Cape
University of Cape Town Lung Institute, Mowbray, Western Cape, 7700, South Africa
Infinity Dermatology Inc, Durban, South Africa
Meditrial, Pietermaritzburg, South Africa
Global Clinical Trials, Pretoria, 0157, South Africa
Sandton Medical Research Centre, Sandton, South Africa
Allergy and Asthma Centre, Westville, South Africa
Seoul Teugbyesolsi
Hanyang University Seoul Hospital, Seongdong, Seoul Teugbyesolsi, 40763, South Korea
Korea University Ansan Hospital, Ansan, 15355, South Korea
CHA Bundang Medical Center, CHA University, Seongnam-si, 13496, South Korea
Seoul National University Bundang Hospital, Seongnam-si, South Korea
Seoul National University Hospital, Seoul, 03080, South Korea
Asan Medical Center, Seoul, 05505, South Korea
Ajou University Hospital, Suwon, 16499, South Korea
Barcelona
Corporació Sanitaria Parc Taulí, Sabadell, Barcelona, 8208, Spain
Hospital General Universitario Dr. Balmis, Alicante, 03010, Spain
Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Hospital Universitari de Bellvitge, Barcelona, Spain
C.H. Regional Reina Sofia, Córdoba, 14004, Spain
Future Meds Madrid, Madrid, 28002, Spain
Hospital Clínico San Carlos, Madrid, 28040, Spain
Complejo Asistencial Universitario De Salamanca, Salamanca, 37007, Spain
Hospital Universitario de la Plana, Villarreal de Huerva, 12540, Spain
National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, 300, Taiwan
Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan
Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
China Medical University Hospital -PPDS, Taichung, 40447, Taiwan
Taichung Veterans General Hospital, Taichung, Taiwan
National Taiwan University Hospital, Taipei, 10002, Taiwan
Taipei Veterans General Hospital, Taipei, 11217, Taiwan
MacKay Memorial Hospital -Taipei branch, Taipei, Taiwan
Chang Gung Memorial Hospital, Linkou, Taoyuan District, Taiwan
Ankara Universitesi Tip Fakultesi Hastaneleri - Cebeci Hastanesi, Ankara, Turkey (Türkiye)
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi, Ankara, Turkey (Türkiye)
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi, Fatih, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Hastanesi, Kocaeli, Turkey (Türkiye)
Erciyes University School of Medicine, Melikgazi, Turkey (Türkiye)
Ondokuz Mayis University Hospital, Samsun, Turkey (Türkiye)
Karadeniz Teknik Universitesi Tip Fakultesi Hastanesi, Trabzon, Turkey (Türkiye)