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Die klinische Studie NCT07278037 für Postpartale Blutung, Geburtskomplikation, Kaiserschnittkomplikationen, Perinatale Probleme ist offene rekrutierung. In der Kartenansicht des Klinische Studien Radar und den KI-Entdeckungstools finden Sie alle Details. Oder stellen Sie hier Ihre Fragen.
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Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage 648 Postpartal

Offene Rekrutierung
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Die klinische Studie NCT07278037 ist eine beobachtungsstudie zur Untersuchung von Postpartale Blutung, Geburtskomplikation, Kaiserschnittkomplikationen, Perinatale Probleme und hat den Status offene rekrutierung. Die Studie startete am 1. Dezember 2025 und soll 648 Teilnehmer aufnehmen. Durchgeführt von Mahidol-Universität ist der Abschluss für 30. September 2026 geplant. Die Daten von ClinicalTrials.gov wurden zuletzt am 22. Dezember 2025 aktualisiert.
Kurzbeschreibung
Postpartum hemorrhage (PPH) is the global leading cause of maternal death, with 20-30% of maternal deaths in Thailand linked to hemorrhage. The WOMAN Trial (2017) provided strong evidence that administering tranexamic acid (TXA)within three hours of bleeding onset lowered PPH-related mortality by 31%. Consequently, the World Health Organization (WHO) updated its guidelines, recommending TXA as part of the standard tr...Mehr anzeigen
Ausführliche Beschreibung
Postpartum hemorrhage (PPH) is the foremost global cause of maternal mortality and represents a critical public health challenge. While the frequency of PPH varies worldwide, its prevalence remains markedly higher in developing nations. For instance, in Thailand, maternal death rates were reported between 20.0 and 40.5 per 100,000 deliveries from 1990 to 2015, with PPH accounting for 20% to 30% of these fatalities. S...Mehr anzeigen
Offizieller Titel

A Retrospective Analysis of the Longitudinal Pattern of Tranexamic Acid Administration in Parturients Undergoing Cesarean Delivery Complicated by Postpartum Hemorrhage

Erkrankungen
Postpartale BlutungGeburtskomplikationKaiserschnittkomplikationenPerinatale Probleme
Weitere Studien-IDs
  • 776/2568(IRB3)
  • Si 717/2025 (Andere Kennung) (Faculty of Medicine Siriraj Hospital Mahidol University)
NCT-Nummer
NCT07278037
Studienbeginn (tatsächlich)
2025-12-01
Zuletzt aktualisiert
2025-12-22
Studienende (vorauss.)
2026-09-30
Geplante Rekrutierung
648
Studientyp
Beobachtungsstudie
Status
Offene Rekrutierung
Stichwörter
cesarean delivery
complications
postpartum hemorrhage
tranexamic acid
Studienarme/Interventionen
Teilnehmergruppe/StudienarmIntervention/Behandlung
Tranexamic acid group
Patients received tranexamic acid after postpartum hemorrhage
Tranexamic acid
The number of patients received tranexamic acid after postpartum hemorrhage
Non tranexamic acid group
Patients did not receive tranexamic acid after postpartum hemorrhage
Nicht zutreffend
Hauptergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
Rate of tranexamic acid administration divided by year
Number of patients received tranexamic acid after diagnosis of postpartum hemorrhage
Within 24 hours after delivery
Nebenergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
Quantity of blood loss
Quantity of blood loss recorded in patients chart
Within 24 hours after delivery
Number of patients received blood transfusion
Number of patients received packed red cells transfusion
Within 24 hours after delivery
Number of patients received additional obstetrical interventions
Number of patients received additional obstetrical interventions such as intrauterine balloon insertion, hysterectomy, uterine artery ligation, B-lynch suture
Within 24 hours after delivery
Number of patients receive reoperation
Reoperation within 24 hours after cesarean delivery
Within 24 hours after delivery
Causes of postpartum hemorrhage
Causes of postpartum hemorrhage divided into 4 categories, 1: uterine atony; 2: abnormal placentation; 3: trauma to internal organ(s); 4:abnormal coagulation
Within 24 hours after delivery
Factors influencing tranexamic acid administration
Identify factors influencing tranexamic acid administration eg. history of antepartum hemorrhage, placental cause of PPH etc.
Within 24 hours after delivery
Side effect of tranexamic acid administration
Side effect of tranexamic acid administration eg. thromboembolism, stroke
After delivery to 30 days
Hospital length of stay
Hospital length of stay in days
After delivery to 30 days
Maternal Mortality
Maternal death rate if death occur
After delivery to 30 days
Teilnahme-Assistent
Eignungskriterien

Zugelassene Altersgruppen
Kind, Erwachsene, Ältere Erwachsene
Zugelassene Geschlechter
Weiblich
  • 1. Patients underwent cesarean delivery with primary postpartum hemorrhage

  1. Gestational age at less than 24 weeks
  2. Absence of the anesthetic record
  3. Received tranexamic acid in the antepartum period
  4. Blood loss less than 1,000 ml
Mahidol University logoMahidol-Universität
Zentrale Studienkontakte
Kontakt: Patchareya Nivatpumin, M.D., +66896662187, [email protected]
Kontakt: Premyuda Matangkarat, M.D., +66959472598, [email protected]
1 Studienstandorte in 1 Ländern

Bangkok

Siriraj Hospital, Bangkoknoi, Bangkok, 10700, Thailand
Patchareya Nivatpumin, M.D., Kontakt, +66896662187, [email protected]
Premyuda Matangkarat, M.D., Kontakt, +66959472598, [email protected]
Offene Rekrutierung