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Sentence Production Training in Aphasia 104 Innovativo

In arruolamento
I dettagli dello studio clinico sono disponibili principalmente in inglese. Tuttavia, Trial Radar IA può essere d'aiuto! Basta cliccare su 'Spiega lo studio' per visualizzare e discutere le informazioni sullo studio nella lingua selezionata.
La sperimentazione clinica NCT05415501 è uno studio interventistico per Afasia, attualmente in arruolamento. Avviato il 1 agosto 2021, prevede di arruolare 104 partecipanti. Sotto la guida di l'Università Purdue, dovrebbe concludersi entro il 30 maggio 2026. I dati più recenti da ClinicalTrials.gov sono stati aggiornati l'ultima volta il 18 dicembre 2024.
Sommario breve
This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.
Descrizione dettagliata
Over five years, the investigators will conduct a series of studies to develop a novel intervention strategy for improving sentence production and comprehension in persons with aphasia. Specifically, the investigators will use implicit learning of grammar as a novel facilitator for language recovery in aphasia. The planned studies seek to test the hypothesis that implicit learning alters the central language system i...Mostra di più
Titolo ufficiale

Structural Priming as a Treatment Component in Aphasia

Patologie
Afasia
Altri ID dello studio
  • IRB-2021-659
Numero NCT
NCT05415501
Data di inizio (effettiva)
2021-08-01
Ultimo aggiornamento pubblicato
2024-12-18
Data di completamento (stimata)
2026-05-30
Arruolamento (previsto)
104
Tipo di studio
Interventistico
FASE
N.D.
Stato
In arruolamento
Parole chiave
aphasia training
aphasia treatment
sentences
grammar
Scopo principale
Trattamento
Allocazione
N.D.
Modello di intervento
A gruppo singolo
Mascheramento
Nessuno (studio in aperto)
Bracci / Interventi
Gruppo/Braccio di partecipantiIntervento/Trattamento
SperimentaleStructural priming training
Participants will be enrolled in 3 sessions of structural priming training (for experiment 1-3) or up to 15 treatment sessions (for experiment 4). Each session will be about 2 hour long, consisting of a set of tasks, including repeating, making, and remembering various types of sentences. In experiment 1-3, each participant will receive two different experimental priming conditions that are being compared within each...Mostra di più
Sentence training
Participants will be trained to read, make, and recall sentences during each session.
Esito primario
Misure di esitoDescrizione della misuraArco temporale
Production of target sentences on action description pictures
Production accuracy (percent correct)
From baseline up to 1-week post training or 2-month post treatment
Comprehension of target sentences in a sentence-to-picture matching task
Comprehension accuracy (percent correct)
From baseline up to 1-week post training or 2-month post treatment
Real-time comprehension of target sentences in a sentence-to-picture matching task
Changes in eye fixations to the target picture
From baseline up to 1-week post training or 2-month post treatment
Esito secondario
Misure di esitoDescrizione della misuraArco temporale
Production of untrained sentences
Production accuracy (percent correct)
From baseline up to 2-month post treatment
Connected speech production - story retell
Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances
From baseline up to 2-month post treatment
Connected speech production - picture description
Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances
From baseline up to 2-month post treatment
Assistente alla partecipazione
Criteri di eleggibilità

Età idonea
Adulto, Adulto anziano
Età minima
21 Years
Sessi idonei
Tutti
Accetta volontari sani
Sì
  • Individuals with post-stroke aphasia
  • At least 6 months post-onset of eft hemisphere stroke
  • Native speaker of English
  • Normal or corrected to normal hearing and vision
  • High-school educated
  • Difficulty communicating in sentences, with some ability to use words independently

  • Severe apraxia of speech
  • Other neurological conditions affecting communication (e.g., dementia)
  • Uncontrolled psychiatric/psychological conditions affecting thinking and communication
  • Active alcohol/substance abuse
Purdue University logoUniversità Purdue39 studi clinici attivi da esplorare
Parte responsabile dello studio
Ji Yeon Lee, Investigatore principale, Associate Professor, Purdue University
Contatti principali dello studio
Contatto: Jiyeon Lee, PhD, 7654943810, [email protected]
Contatto: Jiyeon Lee, 7654943810, [email protected]
1 Centri dello studio in 1 paesi

Indiana

Purdue University, West Lafayette, Indiana, 47907, United States
Jiyeon Lee, Contatto, 765-494-3810, [email protected]
In arruolamento