The Ohio State University Overview

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Ohio State University

The Ohio State University stands as a leading public research institution driving innovative clinical trials across oncology, cardiovascular diseases, and neuroscience, offering patients access to cutting-edge therapies through its extensive network of medical centres and partnerships. Its patient-first approach emphasises equitable trial participation, with a strong focus on diverse populations and real-world outcomes, making it a key player for those seeking advanced treatments in complex conditions.

• Institution Profile: Founded 1870 · Columbus, United States · Public · osu.edu
• Therapeutic Strengths: Cancer, cardiovascular disease, neuroscience
• Research standing: National Cancer Institute designated Comprehensive Cancer Center with an "exceptional" rating; Press Ganey HX Guardian of Excellence Award for Patient Experience in Inpatient Care (9 consecutive years)
• Partnerships: Oncology Research Information Exchange Network (ORIEN) with Moffitt Cancer Center; Nationwide Children's Hospital; Cincinnati Children's Hospital Medical Center (paediatric cancer research); Ohio Perinatal Research Network; Eli Lilly and Company (clinical trials for diabetes medication)

Clinical Research Infrastructure

The Ohio State University's clinical research ecosystem integrates its comprehensive medical centres with specialised affiliates, enabling seamless trial conduct from early-phase studies to large-scale interventions. At its core, the Wexner Medical Center serves as the flagship hub, housing advanced facilities for patient recruitment and data management, while collaborations extend trial reach to regional and national sites. This infrastructure supports over 400 locations worldwide, primarily in the United States, fostering interdisciplinary research in high-enrolment areas like vestibular disorders and preeclampsia.

• Hospitals & Medical Centers: The Ohio State University Wexner Medical Center (primary site for multi-phase trials); Ohio State University Hospital (focus on surgical and interventional studies); Nationwide Children's Hospital (paediatric and perinatal trials)
• Specialty Institutes & Research Facilities: The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (oncology excellence); Biomedical Research Tower (translational research in metabolic diseases); Byrd Polar and Climate Research Center (environmental health studies, though less clinical-focused)

Key Specialties and Therapeutic Focus

The Ohio State University excels in cancer research, particularly surgical oncology and haematology, targeting sarcomas, pancreatic cancer, and leukaemia through minimally invasive procedures and targeted biologics. In cardiovascular disease, it addresses heart failure and related conditions using devices and behavioural interventions, while neuroscience efforts concentrate on spinal cord injuries, Alzheimer's disease, and sensory disorders like loss of smell via innovative diagnostics and radiation therapies. Diabetes and metabolic diseases form another pillar, with emphasis on glycemic control through continuous glucose monitoring and dietary supplements, alongside transplantation studies advancing organ compatibility.

• Therapeutic modalities employed: Small molecules and drugs (97 interventions); biologics (15); procedures (122); behavioural therapies (135); devices (51)
• Leading specialists and their credentials: Raphael E. Pollock (Surgical Oncology, Sarcoma, Head of Surgical Oncology Division); Susan Tsai (Surgical Oncology, Pancreatic Cancer, expertise in robotic procedures); John C. Byrd (Haematology, Leukemia, D. Warren Brown Chair of Leukemia Research); Douglas Scharre (Neurology, Alzheimer's and Cognitive Disorders, Director of Cognitive Neurology); Rami Kahwash (Cardiology, Heart Failure, interventional cardiologist)
• Notable treatment breakthroughs and clinical outcomes: Launched the world's first clinical trial of a device to alleviate heart failure with preserved ejection fraction symptoms (2023); developed a new blood test to predict preterm birth (2024); pioneered the robotic Whipple procedure for pancreatic cancer, reducing recovery time; first to test non-invasive treatment for loss of smell, improving sensory recovery rates

The Ohio State University Clinical Trials Landscape

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As a lead sponsor, The Ohio State University oversees 274 active clinical trials, drawing from a total of 455 trials including collaborator roles, with 273 currently in recruiting, not yet recruiting, or active-not-recruiting statuses as of September 16, 2025. These efforts encompass 175,358 total enrolments across 410 locations, predominantly in the United States, and feature an average of 642 participants per trial, highlighting robust recruitment in conditions like benign paroxysmal positional vertigo (BPPV) and preeclampsia. The portfolio skews towards adults (256 trials) and older adults (222), with 217 interventional and 56 observational studies, emphasising drug (97) and procedural (122) interventions at key sites such as the Wexner Medical Center.

Key Clinical Trial Updates

Recent updates include 24 trials modified in the past month, reflecting ongoing adaptations in diabetes and oncology studies amid evolving regulatory landscapes. Interim analyses from heart failure device trials (initiated 2023) suggest promising symptom relief, with primary completions anticipated in late 2025 and potential FDA submissions by mid-2026. Breakthrough approvals, such as the preterm birth prediction test (2024), underscore successes in maternal health, while robotic surgery advancements continue to yield superior outcomes in pancreatic cancer trials.

Trial Innovation

The Ohio State University pioneers patient-centric designs, including adaptive protocols in neuroscience trials for Alzheimer's that adjust based on real-time cognitive biomarkers. Decentralised elements appear in diabetes studies via remote continuous glucose monitoring, enhancing accessibility for rural participants. Integration of real-world evidence from electronic health records supports observational arms in cardiovascular research, accelerating insights into metabolic outcomes.

Clinical Trial Participation Guide

Use Trial Radar's participation assistant to simplify trial details, preview steps with What to Expect, and confirm eligibility using Check Eligibility for Ohio State University studies. Explore the Contacts & Locations tab to view site-specific information and connect directly with study teams at facilities like the Wexner Medical Center.

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